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Gastrointestinal Protection Demonstrates protective effects on the stomach and intestines , including reducing ulcers and inflammation in animal models2356

For instance, in murine models, HFD was shown to induce hypothalamic inflammation, characterized by increased pro-inflammatory cytokine expression, activation of transcription factor NF-B, microglial activation, and increased levels of local cytokines [47, 48]

By inhibiting NNMT, 5-Amino-1MQ increases nicotinamide pool availability (NAD+ precursors), elevates cellular SAM supporting methylation reactions, reduces adipogenesis, and enhances energy expenditure through improved mitochondrial function

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