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If you develop persistent, severe side effects or fail to respond with at least 5% weight loss in 3-6 months, your prescriber may reassess suitability and explore alternative therapies or interventions

Furthermore, no clinically relevant change in international normalised ratio response to warfarin was observed with semaglutide co-administration

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Introducing steric blockade has proven a successful strategy to increase the stability of a peptide in vivo but typically this has been at the expense of potency, as for instance a 48-fold difference at human GLP-1R in transfected CHO cells between Ab#2_DSB#1 and the same molecule without the disulphide bridge (Ab#2_EX4)