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FOXO4-DRI targets the specific FOXO4-p53 anti-apoptotic interaction in senescent cells
1 Introduction Central nervous system (CNS) injuries, including neurodegenerative diseases and stroke, pose a significant global health burden as the leading cause of disability and the second most common cause of death globally ( Ferroptosis, first described in 2012, is an iron-dependent form of regulated cell death characterized by: (1) accumulation of lipid peroxides and reactive oxygen species (ROS), (2) distinct mitochondrial morphology including shrinkage and cristae reduction, and (3) dependence on iron metabolism (Yao et al., 2021)
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