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1 Introduction While Roux-en-Y gastric bypass (RYGB) leads to substantial and sustained weight loss (WL) in the majority of individuals, along with significant improvements or even resolution of obesity-related conditions, especially type 2 diabetes (T2D) ( Although the mechanistic aspects of metabolic bariatric surgery (MBS), consisting in gastric volume restriction and intestinal malabsorption, were initially thought to be the only culprits for the observed response to MBS, it is long known that they are just part of the equation

Liraglutide lowers body weight set point in DIO rats and its relationship with hypothalamic microglia activation