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They: Produce collagen Organize extracellular matrix Restore tensile structure In experimental tendon transection models, BPC-157 has been associated with: Increased fibroblast density Enhanced migration into injury site Accelerated granulation tissue formation Proposed signalling involvement includes: FAK (Focal Adhesion Kinase) activation ERK1/2 signalling Src pathway modulation FAK signalling is particularly important because it regulates: Cell adhesion Cytoskeletal reorganization Migration along collagen scaffolds Tendon strength depends not just on collagen quantity but alignment
For example, in the TRANSFORMER study, patients with mCRPC who had not received prior BAT exhibited a PSA 50 response rate of 25% and median response duration of 3.8 months while on the AR inhibitor enzalutamide, while patients who had progressed on BAT exhibited a PSA 50 response rate of 78% and median duration of response of 10.9 months while on enzalutamide (9)
Presse medicale (Paris, France : 1983)
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