You should contact your GP or prescribing clinician if you experience: Persistent or severe nausea and vomiting that prevents adequate fluid or food intake, as this may lead to dehydration Severe or persistent abdominal pain , particularly if localised to the upper abdomen, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 agonists) Unexplained weight loss beyond what is expected from the medication's therapeutic effect Changes in bowel habit lasting more than a few weeks, including persistent diarrhoea or new-onset constipation Signs of malabsorption , such as pale, floating, foul-smelling stools (steatorrhoea), which may indicate pancreatic insufficiency Symptoms that significantly impair quality of life or prevent you from continuing your medication Right upper quadrant pain, fever, or yellowing of the skin/eyes , which could indicate gallbladder disease (a reported risk with GLP-1 medications) [16] [17] Seek urgent medical attention via NHS 111 or 999 if you develop severe, persistent upper abdominal pain, especially with vomiting

both these factors may improve brain health and explain the reduced risk of conditions like Alzheimers disease and dementia. While GLP-1RA drugs display effectiveness against a wide array of health problems, the magnitude of associated benefits is modest about a 10 percent to 20 percent reduction for most outcomes
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Bcr-Abl induces autocrine IGF-1 signaling [PMID: 18246120] Laboratory literature summary: Bcr-Abl induces autocrine IGF-1 signaling