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The presence of the mixed disulphide observed in all of our crystallographically independent copies of the complex supports the notion that Sec498 hTrxR1 is the attacking residue of the intra-molecular disulphide in oxidized hTrx1

Dysfunction of cystinosin results in the intralysosomal accumulation of the disulfide cystine, which crystallizes in some tissues and damages many parenchymal organs

Common applications include reconstituting injectable antibiotics (such as ceftriaxone and vancomycin), preparing hormonal and biologic formulations, supporting sterile compounding workflows, and diluting medications for IV, IM, or SC delivery

Zero-order kinetics make dose titration challenging