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These three drugs were approved based on cardiovascular safety data from their development programmes, and each was later followed by a dedicated CVOT: exenatide with EXSCEL, 5 albiglutide with Harmony Outcomes 6 and dulaglutide with REWIND

Moreover, a slight reduction in the inhibitory ability was observed when residue M44 was substituted with alanine

Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial