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Supplementary Figure 6 T cell-specific analysis

The internalized glucose molecule is initially converted to glucose 6-phosphate (G6P) by hexokinase, and then it produces pyruvate through glycolysis as well as abundant reduced nicotinamide adenine dinucleotide phosphate (NADPH) and ribose 5-phosphate through the PPP [17]

hCiPSCs-Treated Group At the genus level, hCiPSCs treatment in the VPA-induced ASD model induced substantial shifts in gut microbiota composition (Figure S2C), with Bifidobacterium and Akkermansia exhibiting the most significant enrichment, accompanied by notable increases in Faecalibaculum and Christensenella