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10.1073/pnas.1609980114 21 ChenL

Thymosin beta-4derived peptides such as TB-500 are widely investigated in wound-healing research because actin-mediated cellular migration is essential for epithelial repair, fibroblast movement, and structural reorganization of damaged tissue

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303 In parallel, EZH2 inhibitors (EZH2is), exemplified by tazemetostat, have shown clinical activity in biomarker-defined populations, particularly in lymphomas and selected solid tumors, and are being tested in combination regimens to overcome lineage plasticity and resistance associated with chromatin reprogramming