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These are recognised clinical barriers to weight management not personal failings and may benefit from specialist support alongside pharmacological treatment
Back Secher, A, Jelsing, J, Baquero, et al (2014) 'The arcuate nucleus mediates GLP- 1RA liraglutide- dependent weight loss', Journal Clinical Investigation , 124, 447388
The mechanism of GLP-1 agonists involves slowing gastric emptying, which prolongs the feeling of fullness after eating and, in turn, tends to reduce the frequency of eating
Preclinical research indicates GHK-Cu may extend this phase, but equivalent human evidence is lacking
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