SUSTAIN (T2D outcomes), STEP (obesity), SELECT (cardiovascular outcomes in non-diabetic obesity), and ongoing programmes in NASH/MASH, Alzheimer's, addiction neuroscience, and heart failure
The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, compared tirzepatide directly against a GLP-1 comparator over 72 weeks
Wegovy works best alongside healthy lifestyle changes: Follow a reduced-calorie diet as recommended by your healthcare provider Increase physical activity, aiming for at least 150 minutes of moderate exercise per week Eat more vegetables, fruit, whole grains and lean proteins Reduce sugary drinks, processed foods and high-fat foods Get adequate sleep (79 hours per night) Manage stress through relaxation techniques Stay hydrated by drinking plenty of water, which is important to reduce the risk of dehydration if you experience vomiting or diarrhoea Switching from Wegovy Injection to Wegovy Pills You can discuss switching from Wegovy injection to Wegovy Tablets with your NowPatient clinician
That's part of why it's so hard to reliably study these kinds of natural compounds
