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Lastly, among rats, the administration of wortmannin (a fungal metabolite) which induces hyperphosphorylation of tau in hippocampal pyramidal neurons, can be partly attenuated by preinjection of melatonin [117, 118], underscoring melatonins potential therapeutic role

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Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

Therefore, the increased expression of KLOTHO resulting from treatment with valsartan and fluvastatin may yield highly positive effects in inhibiting cell senescence and promoting overall cellular protection [132, 134] (Table 2)