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In addition, studies have found that TMAO increases NADPH oxidase activity, induces the production of ROS, and an increase in ROS can promote the translocation of NF-B from the cytoplasm to the nucleus (68)
A prespecified subgroup analysis showed meaningful improvement in OS of 3.5 months (HR, 0.75) with SG in NSCLC that was non-responsive to last anti-PD-(L)1-containing regimen
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