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H.et al (2007)
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Because no long-duration human studies exist, the consequences of months or years of repeated dosing on the immune system, hormonal axes, or fibrotic tissue remodeling are simply unknown
For example, emerging protein targets like IL-4, IL-10, IL-15, IL-17, IL-18, IL-23, interleukin-1 receptor-associated kinase (IRAK)-4 have been revealed to have a strong implication with innate and adaptive immune response in RA ( Protein Targets for Treatment of Rheumatoid Arthritis Currently, many agents aiming at various protein targets have been explored and tested to ease the progression of RA, and some agents have been used in the clinic to treat RA patients ( Table 1 )
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