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Semaglutide activates GLP-1 receptors in your brain and gut, which slows stomach emptying and signals fullnesseffects that often trigger nausea as your body adjusts
Eric Topol, in a July 2025 review of the evidence on peptide therapies, grouped ipamorelin with CJC-1295 and tesamorelin as growth-hormone-related peptides that "carry the potential risk of cancer" on mechanistic grounds, because sustained IGF-1 elevation promotes cell proliferation broadly [4]
In bone, GIP may be a critical factor linking meal intake and bone formation [4] while GLP-1 has no direct effect on bone metabolism and inhibits bone resorption indirectly through upregulation of calcitonin [13]
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