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Pre-clinical research conducted primarily in animal models informs the hypotheses for its use, but no large randomized controlled trials in humans have confirmed efficacy for any outcome - including gut-lining support, tissue-related processes, or any other claimed mechanism
There is no robust evidence that sublingual preparations offer a clinically meaningful advantage over standard oral tablets at equivalent doses
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
Overall Safety and Tolerability Assessment The primary safety conclusion from the comprehensive trial program was unambiguous: AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo
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