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They may also appear if dehydration or low blood sugar is present

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The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression

This approval is supported by data from the Phase II NOBILITY and Phase III REGENCY studies, where Gazyva demonstrated superior efficacy over standard therapy alone, with nearly half of patients achieving complete renal response