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GSH is essential for immunomodulation of both innate and adaptive immune system functions, including T-lymphocyte proliferation, polymorphonuclear neutrophil phagocytosis, and dendritic cell functions, and is also important for fine-tuning the innate immune response to infection and for the first step of adaptive immunity involving antigen-presenting cell (macrophages, dendritic cells)-related antigen presentation (Morris et al., 2013
Two more recent studies investigating the risk of stroke in G6PD-d subjects in China concluded that G6PD-d was associated with significantly increased risk of large vessel atherosclerosis, stroke history, and intracranial atherosclerotic stenosis (ICAS) 20,21
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Mol Cell 15: 767776 Hwang C, Sinskey AJ, Lodish HF (1992) Oxidized redox state of glutathione in the endoplasmic reticulum
