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Peripherally, they primarily act on the pancreas and gastrointestinal tract, stimulating insulin secretion and inhibiting glucagon secretion when blood glucose levels rise, thereby exerting a hypoglycemic effect [60]
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No Increased Neuropsychiatric Risks: Importantly, semaglutide was not associated with an increased risk of adverse neurological or psychiatric outcomes, such as depression, anxiety, or suicidal ideation
The disease spectrum of MASLD ranges from benign hepatic steatosis to more severe forms, including metabolic steatohepatitis (MASH), which can progress to liver fibrosis, cirrhosis, and ultimately, liver failure
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