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During the transition: Monitor blood glucose more frequently for the first 4 to 6 weeks Expect potential hypoglycemia risk if also taking insulin or sulfonylureas Your provider may need to adjust other diabetes medications A1C improvements may be more pronounced with tirzepatide The SURPASS clinical trials demonstrated that tirzepatide 15 mg reduced A1C by up to 2.58%, compared to semaglutide 1 mg which reduced A1C by 1.86%
Variants in GIPR (the GIP receptor relevant to tirzepatide's dual mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide
4F) and non-mitochondrial OCR (Fig
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