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Phase 3 trials evaluating oral semaglutide in early-stage symptomatic Alzheimers disease did not meet their primary endpoints, tempering the earlier hypothesis that GLP-1s might offer direct neuroprotective benefits

This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]

A patient of mine, a veteran who had tried to quit smoking for over a decade, told me that after he started a GLP-1 drug for his diabetes, he lost interest in cigarettes