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Then I did a bunch of in vitro receptor activation assays to demonstrate that the molecule I designed interacted with the GLP-1 and GIP receptors, which is actually not something you can really measure in the body, where you have to look at things like impact on weight or glycemic control. Animal studies then followed, which were really all about safety and toxicity to demonstrate that even at extremely high levels, it wouldnt be dangerous, he added
The slightly higher female response reflects known gender differences in fat distribution and hormonal response to GLP-1 pathway activation
Clin Exp Rheumatol (2020) 38(4):71323
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