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UchidaK.ShiraishiM.NaitoY.ToriY.NakamuraY.OsawaT.1999Activation of stress signaling pathways by the end product of lipid peroxidation, 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production.Journal of Biological Chemistry.274223422420021-9258 70
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Thus, unlike WT-Bcr-Abl cells, T315I-Bcr-Abl cells are less vulnerable to JMF4073 in vitro and in vivo
Furthermore, pretreatment of cultures with liraglutide attenuated measures of synapse induced by A oligomers (AOs), but liraglutide failed to prevent AOs-induced synapse loss after treated PKA inhibitor, and liraglutide attenuated the AOs-induced decrease of PKA activity, suggesting that activation of the cAMP/PKA pathway underlies the neuroprotective actions of liraglutide (176)
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