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Published online June 21, 2024
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STAT3 overexpression is a key molecule that drives the progression of hepatocellular carcinoma, and its activation may be critical in initiating oncogenesis
They hint at a narrow therapeutic window in a biologically distinct subgroup: younger patients, usually with alcohol-related disease, higher baseline MELD-3 but preserved albumin, and clear evidence of systemic inflammation (higher CRP) in whom improvements in inflammatory markers parallel meaningful improvements in MELD-3 and outcomes
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