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That single fractionation study is the proof point researchers still cite more than fifty years later as the origin of the entire copper-peptide research field: a compound identified almost by accident in a liver-aging comparison went on to become one of the most studied metallopeptides in dermal and regenerative research

and the University of Virginia

Across the 1980s and 1990s, GHK-Cu was studied extensively in wound healing applications, where it consistently demonstrated the ability to accelerate skin repair, stimulate collagen and glycosaminoglycan synthesis, and reduce inflammation at the site of injury

Vitamin B12 injections are primarily used to treat pernicious anemia and vitamin B12 deficiency