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Some protocols recommend intramuscular injection into the worked muscle ("site injection"), with the theory that local IGF-1R stimulation drives localized hypertrophy
Be cautious with compounded medications Compounded GLP-1 formulations show 2.5 times higher hospitalization rates compared to FDA-approved products
Triple agonism (GLP-1 + GIP + glucagon) is a real mechanistic advance, not just marketing but the full implications, especially for muscle mass, aren't confirmed yet
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