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2MASLD [1] 2015201950% [1] 2030 70.56.1 [2] -1GLP-1RA [1-4] GLP-1RAGLP-1GLP-1R [2] 2024 [2] cAMP -arrestin [1] 1 GLP-1RA cAMP -arrestin cAMP GLP-1RA [1-3] 2 GLP-1RA [1-3] 1GLP-1RA GLP-1RAGLP-1GLP-1/GIPGLP-1/GCGGLP-1GIPGCG [5,6] GIPGIPRGLP-1 [ 2 ] [7] GLP-1 -arrestin GIP -arrestin GIP GCG GCG GLP-1 GLP-1 GCG [2] GCG GCGR [6] [8] [1] [6,8] 2 GLP-1RA [9] GLP-1RA EcnoglutideOrforglipronGSBR-1290SAL0112DD202-114 [9] G/cAMP-arrestin GLP-1RA [9] GLP-1RA 2012 G GPCR [ 4 10] GLP-1RA GLP-1GcAMP-arrestin [11] -GLP-1 [ 11 ] 3 GLP-1RA GLP-1RA GLP-1 Kd 10 [11] SLIMMER [1] cAMP cAMP-arrestin [11] SLIMMER 48 [1] GLP-1RA - - - - 2030 21 SCI 120 1.Ji L, Gao L, et al

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N Engl J Med 2021;384:1113-1124

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