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Abbreviations CVD: Cardiovascular disease HF: Heart failure HFrEF: Heart failure with reduced ejection fraction IV: Intravenous ID: Iron deficiency TSAT: Transferrin saturation FCM: Ferric carboxymaltose DCYTB: Duodenal cytochrome B CRT: Cardiac resynchronization therapy CMR: Cardiac magnetic resonance ROS: Reactive oxygen species ATP: Adenosine triphosphate Fe: Iron FPN: Ferroportin sTfR: Soluble transferrin receptor TIBC: Total iron-binding capacity HIF: Hypoxia-inducible factor IL: Interleukin eNOS: Endothelial nitric oxide synthase HFE: Hemochromatosis gene AHA: American Heart Association ACC: American College of Cardiology HFSA: Heart Failure Society of America ESKD: End-stage kidney disease References WHO

KerksickCMArentSSchoenfeldBJStoutJRCampbellBWilbornCDet al

After 5 hours in gastric juice equivalent pH3.0, BPC-157 is degraded only 15.1% versus the acetate salt version which is over 99% destroyed