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10.1152/AJPGI.00537.2010 19 GaoJ.CahillC
Vitamin C promotes apoptosis and cell cycle arrest in oral squamous cell carcinoma
In a study on particulate matter-induced lung injury, ACOD1 deficiency did not impair Nrf2 activation, suggesting that endogenous itaconate is not essential for Nrf2 activation
In ovarian cancer, it has shown promise by targeting the tumor microenvironment, specifically by suppressing the polarization of macrophages into the M2 pro-tumor phenotype, a shift usually triggered by interleukin IL-4 and IL-13 exposure
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