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In the meta-analysis of 3 studies 20,28,32 which compared a GLP-1-based therapy against a comparator, GLP-1-based therapies were found to increase % FMD non-significantly (mean difference [95% CI] in the changes from baseline: 1.65 [0.89, 4.18] %
MT-1 binds to melanocortin-1 receptors (MC1R) on melanocytes to stimulate eumelanin synthesis without the appetite suppression or sexual side effects associated with melanotan-2, making dose titration more straightforward
Focus on light, easily digestible meals for the first 24 to 48 hours
Separate clinical trials suggest similar weight loss results, but the studies were not designed as a head-to-head comparison
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