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Ferroptosis and AD pathology Amyloid (A) plaques and neurofibrillary tangles (NFTs) A plaque accumulation is a hallmark pathological feature of AD, where abnormal A aggregation disrupts synaptic function and impairs memory (30,31)
GLP-1 receptor agonists slow gastric emptying, causing constipation in more than 1 in 10 people on higher doses (Wegovy, Saxenda)
Long-acting GLP-1RAs also have other benefits including improved gastrointestinal tolerability, moderate plasma drug concentration fluctuations, and more convenient dosage regimens which may improve medication adherence and treatment outcomes [11] (Table 1)
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