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Supports investigation of tissue structural rejuvenation: Accumulated senescent cells can impair tissue architecture by altering cell-to-cell communication and extracellular matrix composition
Systemic anti-aging and injectable regeneration claims are weakest because they lack strong human confirmation and face regulatory safety concerns [8], [17]
The 15-year follow-up of the DPP Outcomes Study (DPPOS) confirmed durable benefit: cumulative diabetes incidence remained 27% lower in the original lifestyle group [5]
Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jger S, Aguilaniu H (2018) A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response
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