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After injection (monitoring phase) Immediately: Apply cold compress for 10 to 15 minutes First hour: Monitor for any unusual symptoms beyond the injection site First 24 hours: Repeat cold compress every 2 to 3 hours if a reaction develops First 48 hours: Apply hydrocortisone 1% twice daily if redness or itching persists Day 3 to 7: Switch to warm compress if swelling or lumps remain
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This is achieved by detergent removal of mixed micelles, dialysis, and gel permeation chromatography
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