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We first performed a series of syngeneic transplantation experiments using isogenic KP, Fsp1 KO and Fsp1 WT cell lines with no proliferation differences in vitro to systematically characterize the impact of Fsp1 loss on tumor growth and further interrogate whether Fsp1-mediated tumor differences were specific to in vivo growth conditions (Fig

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The weighted mode is based on the assumption that a plurality of genetic variants are valid instruments, i.e., no larger subset of invalid instruments estimating the same causal parameter than the subset of valid instruments exists [44]

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