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The combination carries low hypoglycaemia risk when used alone, but gastrointestinal side effects (nausea, vomiting, diarrhoea) are common and may be more pronounced initially
If a cell has sufficient ATP (like a fully charged battery), it powers a pump called Na/K-ATPase to immediately pump that sodium back out
1 This is typically a silent disease, often not producing symptoms until its later stages when there is chronic liver injury
Interestingly, inhibition of NLRP3 inflammasome activation reversed the M1 polarization of TMAO-stimulated macrophages, suggesting that NLRP3 plays a crucial role as a proteolytic activator in TMAO-induced macrophage responses
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