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SIPS is a phenomenon characterized by the irreversible cessation of the division of normal cells even in presence of nutritional and mitogenic factors 27

Moreover, with the expression of CD73 and CD39, Treg cells catalyze ATP to adenosine, which inhibits the function of effector T cells (Vignali et al., 2008)

Additionally, they discovered that the centenarians had higher levels of glutathione than people 20 to 40 years younger, hinting that glutathione may be one reason why their subjects had lived to such a ripe age

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