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These unpleasant burps typically occur during the initial weeks of treatment or following dose increases, often resolving within a few weeks as the body adapts
Healthcare professionals should maintain a low threshold for referring patients with complex bone health needs to endocrinology or metabolic bone disease specialists
Weeks 1-4 Starting dose to assess tolerance Weeks 5-8 First dose increase Weeks 9-12 Therapeutic effects begin Weeks 13-16 Approaching target dose Week 17+ Full maintenance dose Side Effects & Safety Most gastrointestinal side effects are mild, temporary, and occur during the dose escalation period
However, practical factors such as cost, patient adherence, and tolerability often make an add-on approach more feasible in real-world settings
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