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More serious but less common risks include pancreatitis, gallbladder disease, hypoglycemia (particularly when combined with insulin or sulfonylureas), and potential thyroid C-cell tumors (observed in animal studies, though human relevance remains uncertain)
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Ozempic is the only FDA-approved oral peptide GLP-1 medication for adults with type 2 diabetes indicated not only to improve blood sugar, along with diet and exercise, but also to reduce the risk of major cardiovascular events (MACE) such as heart attack, stroke, or death in those who are also at high risk for these events.1 Oral semaglutide for type 2 diabetes has been available as Rybelsus in a different formulation and set of doses
Other oral GLP-1 medicines are being studied, including orforglipron, but these are not currently licensed in the UK for weight loss
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