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Biochem J 210:899903 Lelarge-Trouverie C, Cohen M, Trmulot L, Van Breusegem F, Mhamdi A, Noctor G (2023) Metabolite modification in oxidative stress responses: a case study of two defense hormones

While NSAIDs impair recovery through gut injury, nutrient depletion, cardiovascular strain, and delayed tissue repair, opioids alter pain through a fundamentally different mechanismsuppressing central pain perception without addressing inflammatory or structural drivers

It also comes with potential and pesky side effects such as scalp irritation, flaking, and unwanted facial hair

MRI revealed symmetrical white matter lesions in the corticospinal tract (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury (Bora et al., 2012)