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In summary, the therapeutic rationale for dual GLP-1/GIP receptor agonists in the treatment of obesity and Type 2 Diabetes is to harness and enhance the physiological roles of these incretins in glucose regulation and weight management, while optimizing the drug's signaling to improve efficacy, duration of action, and tolerability.The science underpinning the use of GLP-1 and GIP receptor agonists in the treatment of obesity and type 2 diabetes (T2D) is well-established, but some aspects are still subject to ongoing research and debate

The biological activities of vitamin D and its receptor in relation to calcium and bone homeostasis, cancer, immune and cardiovascular systems, skin biology, and oral health

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Over the four-year period, the percentage of female patients with a semaglutide or tirzepatide prescription who also had PCOS increased from 4.6% in 2021 to 5.7% in 2025, representing a 23.9% relative increase