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Its weight-loss version, Wegovy, changed the field when it was approved as a once-weekly injection in June 2021

UHCs 2026 commercial PA criteria for Wegovy require five elements: BMI of 30 or higher, or BMI 27 to 29.9 with at least one weight-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, OSA, CVD), documentation of a structured weight management program for at least 6 months in the past 24 months, prescriber attestation that lifestyle changes alone have been inadequate, age 18 or older, and concurrent reduced-calorie diet and physical activity

This blockade inhibits the downstream Smad2/3 pathwaywhich otherwise promotes muscle protein degradation and atrophyand instead promotes muscle hypertrophy and differentiation [175]

Diet and Lifestyle : Following a balanced diet and incorporating physical activity can help amplify the effects of semaglutide