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hypoglycemia risk if on insulin) eGFR below 30 (tirzepatide exclusion in SURMOUNT-5) Recent cardiac event or NYHA Class IV heart failure Active suicidal ideation (trials excluded PHQ-9 scores of 15 or above) If your tirzepatide vs semaglutide question is pure weight loss without comorbidities, tirzepatide wins on the numbers
Atenolol produces CNS effects similar to other beta-blockers, but does so to a lesser extent due to reduces ability to cross the blood-brain barrier
It is a poorer fit, or warrants caution, in patients with known sulfur or sulfite sensitivity, in poorly controlled asthma, and in anyone whose expectations are anchored to unproven claims particularly cosmetic skin-lightening
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