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Hence, EGCG protects mitochondrial respiratory enzymes and decreases mitochondrial ROS production in cisplatin-induced nephrotoxicity (Sahin et al., 2010
Evidence has shown their capability to increase the expression of NRF2 target genes in cellular and in vivo models of chronic obstructive pulmonary disease (COPD) [298], and to interfere with the direct PPI between KEAP1 and NRF2 or the PPI between KEAP1 and CUL3 [299, 300]
10.1016/j.clinthera.2017.10.016 86
Comparative and Combination-Therapy Evaluations : Comparing the combination versus cagrilintide alone, semaglutide alone, and placebo to clarify additive or distinct effects within the study design
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