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Additionally, both studies compared GLP-1RAs with SGLT-2 inhibitors, but the risk of intestinal obstruction associated with GLP-1RAs compared to other commonly used anti-diabetic medications, including insulin and metformin, remains unknown
To mitigate potential discrepancies in baseline characteristics between the two study groups, we comprehensively integrated and algorithmically selected high-dimensional covariates assessed within 1 year before the index time
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The review also frames GLP-1RA use against the backdrop of rising obesity rates, substantial health care costs, and the high overlap between obesity and diagnosed diabetes
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