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In the first scenario, IBS (K58) and major depression (F33)two comorbid conditions with shared pathophysiological mechanisms 83 were linked by lubiprostone, a drug used to treat constipation, a common manifestation of both diseases 84 (see Fig

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Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review)