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Following heme internalization, heme oxygenase-1 (HMOX-1) degrades heme to produce bilirubin, carbon monoxide, and ferrous ions, which inhibit the interactions of iron-binding proteins with iron response elements in FPN mRNA, thereby upregulating FPN expression and promoting tumor growth (81)

Although NAC could potentially improve glutathione levels and alleviate oxidative stress, this issue is controversial [43-45]

Le glutathion est un puissant antioxydant endogne qui aide neutraliser les radicaux libres et protger les cellules du stress oxydatif