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Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms
The practical implication for researchers is significant
Those found in the BBB are 50-100 times closer than those found in peripheral capillaries, contributing to restricted transport of molecules
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