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The estimated oral dose range from animal research is approximately 18 mg/kg, but human pharmacokinetic parameters including bioavailability fraction, Tmax, and clearance remain entirely unknown

And that's a cluster set with failure built into it a couple times

Includes: Total glutathione level assessment Sample requirement: Serum Suitable for postal submission.

What else you should know If you don't lose at least 3% of your weight after 12 weeks on Qsymia, the FDA recommends that you stop taking it or that your doctor increase your dose for the next 12 weeks -- and if that doesn't work, you should gradually stop taking it