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pro-apoptotic pathways, including the activation of caspases and prolonged c-Jun NH2 terminal kinase (JNK) signaling, are antagonized by various NF-B target genes 28
Therefore, the role of GLP-1 RAs specifically in the cardiovascular system has been of particular interest in the past several years, and multiple clinical trials have examined the cardiovascular effects and safety of GLP-1 RAs (Table 1)
These findings underscore the importance of developmental context when evaluating the safety and efficacy of GLP-1 receptor agonists in pediatric populations
This is because GLP-1 drugs also dampen inflammatory processes in the body
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